The brain is the human body's most mysterious organ. She has stated that "four years of high school, four years of college, four years of medical school" makes doctors socially inept at times.

She currently lives with her girlfriend Penelope Blake and daughter in New York. She was one of two daughters in a wealthy family, a fact she doesn't like to share with significant others.

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She then invited him to assist her on a cool ortho case.

Before the surgery on the patient, she told him the ball was in his court as that was the last invitation she was giving him.

However, George didn't call her, so Callie started to ignore him.

And, when it's hurt, when the human brain is traumatized, well, that's when it gets even more mysterious.

And no matter how much research we do, no one can really say how all that delicate grey matter inside our skull works.

She has described herself as "a total freak," and "I'm that girl in the back of the class who eats her hair." She had also admitted to Arizona Robbins that she was in the Peace Corps in Botswana, and that is what had convinced her to go to medical school.

Callie met George when she reduced his dislocated shoulder.

While having a short conversation, George told her he was single.

Later that night, Callie ran into George outside the hospital and wrote her phone number on his hand, clearly showing interest in him.